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 Dr. Frans J. van Overveld

Profile
Frans van Overveld was born on 13 April 1959 in Bergen op Zoom, The Netherlands. He studied Medical Biology at the University of Utrecht, The Netherlands, with main directions Haematology and Immunology.
In 1988, he obtained his PhD in Medical Sciences on “Some aspects of mast cell subtypes from human lung tissue” at the same university. In 1991 he was registered as Immunologist.
From 1988 to 2003 he was employed as a postdoctoral scientist at the Department of Respiratory Medicine of the University of Antwerp, Belgium. Here, he was involved in both fundamental and clinical research, the management of a research laboratory, and the education of students. The main areas of interest were inflammatory processes and immunological mechanisms in acute lung injury and chronic obstructive pulmonary disease (COPD) in relation to treatment.
From 2004 to 2008 he was employed as Study Director at PM Research Laboratories in Leuven, Belgium. During this time he focussed on the aspects of cigarette smoking and lung disease.
Since 2009, he is employed as Scientific Writer at 4Clinics, Waterloo, Belgium, where the emphasis is on infectious diseases and prevention.
In 1992, he was awarded the Belgian Award for Allergology and Clinical Immunology, and in 1988, the Staub and Bovet Award, both for his work on mast cells.
He is member of several professional organisations, e.g. Netherlands Respiratory Society, the Dutch Society for Immunology, and the European Histamine Research Society. He is also reviewer for several scientific journals, e.g. European Journal of Pharmacology, Pulmonary Pharmacology and Therapeutics, and International Journal of COPD.
He was member of the Task Force for Induced Sputum of the European Respiratory Society and participated in the organisation of some conferences and courses.
 
 
Selected Publications
  • Beunk L, Verwoerd A, van Overveld FJ, Rijkers GT. Role of mast cells in mucosal diseases: Current concepts and strategies for treatment. Expert Review of Clinical Immunology, in press.
  • Stinn W, Buettner A, Weiler H, Friedrichs B, Luetjen S, van Overveld FJ, Meurrens K, Janssens K, Gebel S, Haussmann H-J. Inflammatory effects, lung tumorigenesis, and emphysema development in a long-term inhalation study with cigarette mainstream smoke in mice. Toxicological Sciences, in press.
  • Demkow UA, van Overveld FJ. Role of elastases in the pathogenesis of chronic obstructive pulmonaryBeunk L, Verwoerd A, van Overveld FJ, Rijkers GT. Role of mast cells in mucosal diseases: Current concepts and strategies for treatment. Expert Review of Clinical Immunology, in press.
  • Demkow UA, van Overveld FJ. Role of elastases in the pathogenesis of chronic obstructive pulmonary
  • Van Overveld FJ, Demkow UA, Górecka D, et al. Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD. Journal of Physiology and Pharmacology (2006) 57, Suppl. 4: 273-282.
  • Radomska-Leœniewska DM, Sadowska AM, van Overveld FJ, et al. Influence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cells. Journal of Physiology and Pharmacology (2006) 57, Suppl. 4: 325-334.
  • Van Overveld FJ, Demkow UA, Górecka D, et al. New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine. Journal of Physiology and Pharmacology (2005) 56, Suppl. 4: 135-142.
  • Van Overveld FJ, Demkow UA, Górecka D, et al. Inhibitory capacity of different steroids on neutrophil migration across a bilayer of endothelial and bronchial epithelial cells. European Journal of Pharmacology (2003) 477: 261-267.
  • Van Overveld FJ, Vermeire PA, De Backer WA. Induced sputum of patients with chronic obstructive pulmonary disease (COPD) contains adhesion promoting, therapy-sensitive factors. Inflammation Research (2000) 49: 8-13.
  • De Backer WA, Amsel B, Jorens PG, Bossaert L, Hiemstra PS, van Noort P, van Overveld FJ. N-acetylcysteine pre-treatment of cardiac surgery patients influences plasma neutrophil elastase and neutrophil influx in bronchoalveolar lavage fluid. Intensive Care Medicine (1996) 22: 900-908.
  • Jorens PG, De Jongh RF, De Backer WA, Van Damme J, van Overveld FJ, et al. Interleukin-8 production in patients undergoing cardiopulmonary bypass: the influence of pre-treatment with methylprednisolone. American Review of Respiratory Disease (1993) 148: 890-895.
  • Van Overveld FJ, Jorens PG, Rampart M, et al. Tumour necrosis factor stimulates human skin mast cells to release histamine and tryptase. Clinical and Experimental Allergy (1991) 21: 711-714.
  • Jorens PG, van Overveld FJ, Bult H, et al. L-arginine dependent production of nitrogen oxides by rat pulmonary macrophages. European Journal of Pharmacology (1991) 200: 205-209.
  • Van Overveld FJ. Staub and Bovet Award 1989 Lecture: Some aspects of mast cell subtypes from human lung tissue. Agents and Actions (1990) 30: 24-29.
  • Van Overveld FJ, Houben LAMJ, Schmitz du Moulin FEM, et al. Mast cell heterogeneity in human lung tissue. Clinical Science (1989) 77: 297- 304.

Courses

SCI 234 Human Physiology​

SCI 362 Infection and Immunity​

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Immunology

P.O. Box 94
NL-4330 AB  Middelburg
Tel:    0118-655528
Fax:    0118-655508